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S2 Fig Secreted galectin-3 expression. In order to demonstrate the putative role of hypoxia in regulating galectin-3 leo in canine mammary tumors CMTin vitro and in vivo studies were performed. In the specific case of Brazil, the authors mention that the state reforms followed the managerial perspective leu to which management practices prevailing in the private sector were taken as reference and transposed to the public sector in order to promote greater efficiency in the state administration and focus on results.

However when untreated CMT-U27 cells were exposed to hypoxia galectin-3 nuclear expression could no longer be found. Galectin-3 translocates to the perinuclear membranes and inhibits cytochrome c release from the mitochondria. A theory of collective competence: Expression of fully and under-glycosylated forms of MUC1 mucin in gastric carcinoma. Extracellular galectin-3 in tumor progression and metastasis. The prognostic value of histological tumor necrosis in solid organ malignant disease: To ldi the existence of such hypoxic areas and whether this would also influence galectin-3 expression in vivoleo inoculated the CMT-U27 cell line into the mammary fat pad of female nude mice and allowed the tumors to grow until they reached approximately mm 3.

After incubation with the appropriate secondary antibodies for 30 minutes at room temperature, the Avidin-Biotin Complex Vector Labs amplification system was applied prior to detection.

No evidence of galectin-3 cleavage was found. The field research was carried out in three federal public organizations. Data Availability All relevant data are available in the manuscript and its Supporting Information files.

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However, attributes of collective competencies were reported by respondents, especially common referential and shared language, as shown in Table 1. To answer that question, a qualitative study was carried out in three federal public organizations: The aforementioned resolution conceptualized the Competency-based Management System as the [ However, remote access to EBSCO’s databases from non-subscribing institutions is not allowed if the purpose of the use is for commercial gain through cost reduction or avoidance for a non-subscribing institution.

The competency-based management model assumes that organizational competencies guide the actions that permeate management subsystems – and among them, people management.

Galectin-3 was increased in CMT-U27 cells under hypoxia 1. Galectin-3 contributes to neonatal hypoxic-ischemic brain injury.

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Despite galectin-3 may be secreted to the extracellular space in an energy-independent manner [ 36 ], our present data seem not to support any additional differences in the secretion of the lectin at different points of hypoxia exposure S2 Fig.

A cost-benefit analysis of bevacizumab in combination with paclitaxel in the first-line treatment of patients with metastatic breast cancer. The report indicates, for example, the situation of the Integrated Management System SIG – UFPB regarding HR and the modules implemented until vacations, training, performance evaluation, requests, and electronic aids and registration.

Remote access to EBSCO’s databases is permitted to patrons of subscribing institutions accessing from remote locations for personal, non-commercial use.

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Galectin-3 and GLUT-1 are up regulated in hypoxic tumor cells surrounding necrotic areas both in primary malignant CMT and lung metastases. Subcellular localization of galectin-3 and GLUT Necrotic tissue exhibiting sections were chosen by the pathologist Gartner, F.

Galectin-3 and the mammary tumor cell marker, MUC1 expression in lung metastasis. Galectin-3 expression in CMT-U27 cell line under hypoxic conditions. Prompted by the need for modernization of management and by the attempt to comply with the PNDP, the organizations under study faced the challenge of implementing a management model meant to be strategic regarding people management, the Competency-based Management Model. That way, the new policy of people training and development would hold this strategic vision when promoting competency–based management as necessary to the public administration.


Blood flow in six human melanoma xenograft lines with different growth characteristics. International journal of clinical and experimental pathology. This may imply that galectin-3 expression is regulated both at the transcriptional and post-transcriptional levels [ 732 ]. Catalase overexpression had no clear effects on the expression or transcriptional activity of HIF1 in human hepatoma cells [ 42 ].

In fact, cells displayed higher expression levels of galectin-3 mRNA 4-fold increase upon 24 hours of hypoxia exposure when compared with normoxic controls.

The later transcriptional activation of galectin-3 could by justified by the need of co-factors up regulated later in the cascade of events following oxygen deprivation, although further studies are needed to prove it. The question that it attempts to answer is the following: The level of 18S RNA in each sample was measured and used for normalization of target gene abundance.

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These results reinforce the difficulties faced by the Brazilian public administration due to the coexistence of the traditional bureaucratic model with premises defended by the managerial model of public administration. The International journal of developmental biology.

In in vivo studies, galectin-3 was overexpressed in hypoxic areas of primary tumors and well-established metastases.